Drug interactions
Paliperidone + Umeclidinium-vilanterol
Severity: Moderate
Paliperidone and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paliperidone can prolong the QT interval and cause tachycardia. Vilanterol may add to these effects, increasing the risk of arrhythmia in susceptible patients.
What this interaction means in plain words
Paliperidone and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paliperidone belongs to Central Nervous System; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Additive QT prolongation and adrenergic cardiac effects.
What to do
Monitor ECG and electrolytes in patients with cardiac risk factors. Avoid adding further QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Frequently asked questions
Can I take Paliperidone with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Paliperidone and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paliperidone can prolong the QT interval and cause tachycardia. Vilanterol may add to these effects, increasing the risk of arrhythmia in susceptible patients.
How serious is the interaction between Paliperidone and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes in patients with cardiac risk factors. Avoid adding further QT-prolonging drugs.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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