Drug interactions
Palonosetron + Tedizolid
Severity: Moderate
Palonosetron and Tedizolid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tedizolid is a weak reversible MAO inhibitor and palonosetron is a 5-HT3 antagonist, and serotonin syndrome has been reported with 5-HT3 antagonists given alongside serotonergic agents. The risk with this particular pair is probably low but cannot be excluded. Features include agitation, tremor, hyperthermia and neuromuscular excitability.
What this interaction means in plain words
Palonosetron and Tedizolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Palonosetron belongs to Gastrointestinal Tract; Tedizolid belongs to Anti Bacterial.
Why it happens
Possible additive serotonergic effects, with weak MAO inhibition by tedizolid; the mechanism for 5-HT3 antagonists is not firmly established.
What to do
Monitor for signs of serotonin syndrome when the two are used together, especially after dose changes. Stop both and give supportive care if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Palonosetron
- Apomorphine + Palonosetron Contraindicated
- Isocarboxazid + Palonosetron Major
- Palonosetron + Phenelzine Major
- Palonosetron + Tranylcypromine Major
- Almotriptan + Palonosetron Moderate
- Amitriptyline + Palonosetron Moderate
Other interactions of Tedizolid
- Bupropion + Tedizolid Major
- Cyproheptadine + Tedizolid Major
- Deferiprone + Tedizolid Major
- Isocarboxazid + Tedizolid Major
- Meperidine + Tedizolid Major
- Methamphetamine + Tedizolid Major
Frequently asked questions
Can I take Palonosetron with Tedizolid?
MediHelp rates the interaction as moderate. Palonosetron and Tedizolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tedizolid is a weak reversible MAO inhibitor and palonosetron is a 5-HT3 antagonist, and serotonin syndrome has been reported with 5-HT3 antagonists given alongside serotonergic agents. The risk with this particular pair is probably low but cannot be excluded. Features include agitation, tremor, hyperthermia and neuromuscular excitability.
How serious is the interaction between Palonosetron and Tedizolid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin syndrome when the two are used together, especially after dose changes. Stop both and give supportive care if symptoms appear.
What other medicines interact with Palonosetron?
MediHelp also lists interactions of Palonosetron with, for example, Apomorphine, Isocarboxazid, Phenelzine. The full list is on the Palonosetron page.
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