Drug interactions
Panobinostat + Salmeterol
Severity: Major
Panobinostat and Salmeterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Panobinostat significantly prolongs the QT interval and salmeterol can contribute to QT prolongation and tachycardia. Together they raise the risk of torsades de pointes. Labeling advises against panobinostat with QT-prolonging drugs.
What this interaction means in plain words
Panobinostat and Salmeterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Panobinostat belongs to Oncology; Salmeterol belongs to Respiratory.
Why it happens
Additive QT prolongation and beta-adrenergic cardiac stimulation.
What to do
Avoid the combination and use an alternative bronchodilator if possible. If unavoidable, monitor ECG and keep potassium and magnesium in range.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Other interactions of Panobinostat
- Amiodarone + Panobinostat Contraindicated
- Anagrelide + Panobinostat Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
- Dronedarone + Panobinostat Contraindicated
- Haloperidol + Panobinostat Contraindicated
Frequently asked questions
Can I take Panobinostat with Salmeterol?
MediHelp rates the interaction as major. Panobinostat and Salmeterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Panobinostat significantly prolongs the QT interval and salmeterol can contribute to QT prolongation and tachycardia. Together they raise the risk of torsades de pointes. Labeling advises against panobinostat with QT-prolonging drugs.
How serious is the interaction between Panobinostat and Salmeterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative bronchodilator if possible. If unavoidable, monitor ECG and keep potassium and magnesium in range.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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