Drug interactions
Panobinostat + Tolterodine
Severity: Moderate
Panobinostat and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Panobinostat inhibits CYP2D6 and raises exposure to sensitive CYP2D6 substrates. Tolterodine uses CYP2D6 as its main route, although the parent and active metabolite changes partly offset, and CYP3A4 can compensate. Both drugs are linked to QT prolongation, which adds concern.
What this interaction means in plain words
Panobinostat and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Panobinostat belongs to Oncology; Tolterodine belongs to Genitourinary.
Why it happens
CYP2D6 inhibition by panobinostat reduces tolterodine metabolism, with additive QT effects.
What to do
Monitor ECG and electrolytes, and watch for anticholinergic effects. Consider a lower tolterodine dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolterodine
Other interactions of Panobinostat
- Amiodarone + Panobinostat Contraindicated
- Anagrelide + Panobinostat Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
- Dronedarone + Panobinostat Contraindicated
- Haloperidol + Panobinostat Contraindicated
Frequently asked questions
Can I take Panobinostat with Tolterodine?
MediHelp rates the interaction as moderate. Panobinostat and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Panobinostat inhibits CYP2D6 and raises exposure to sensitive CYP2D6 substrates. Tolterodine uses CYP2D6 as its main route, although the parent and active metabolite changes partly offset, and CYP3A4 can compensate. Both drugs are linked to QT prolongation, which adds concern.
How serious is the interaction between Panobinostat and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes, and watch for anticholinergic effects. Consider a lower tolterodine dose if adverse effects appear.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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