Drug interactions
Panobinostat + Trastuzumab
Severity: Moderate
Panobinostat and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Panobinostat commonly causes severe thrombocytopenia and neutropenia. With trastuzumab, hematologic toxicity and infection risk may rise.
What this interaction means in plain words
Panobinostat and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Panobinostat belongs to Oncology; Trastuzumab belongs to Oncology.
Why it happens
Additive myelosuppression.
What to do
Monitor complete blood counts closely. Adjust or interrupt panobinostat for significant cytopenias.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trastuzumab
Other interactions of Panobinostat
- Amiodarone + Panobinostat Contraindicated
- Anagrelide + Panobinostat Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
- Dronedarone + Panobinostat Contraindicated
- Haloperidol + Panobinostat Contraindicated
Frequently asked questions
Can I take Panobinostat with Trastuzumab?
MediHelp rates the interaction as moderate. Panobinostat and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Panobinostat commonly causes severe thrombocytopenia and neutropenia. With trastuzumab, hematologic toxicity and infection risk may rise.
How serious is the interaction between Panobinostat and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts closely. Adjust or interrupt panobinostat for significant cytopenias.
What other medicines interact with Trastuzumab?
MediHelp also lists interactions of Trastuzumab with, for example, Daunorubicin, Doxorubicin liposomal, Doxorubicin. The full list is on the Trastuzumab page.
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