Drug interactions
Pantoprazole + Stiripentol
Severity: Minor
Pantoprazole and Stiripentol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits CYP2C19 and BCRP, both involved in pantoprazole disposition, so pantoprazole exposure may increase. Clinical consequences are probably limited.
What this interaction means in plain words
Pantoprazole and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pantoprazole belongs to Gastrointestinal Tract; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol inhibits CYP2C19 metabolism and BCRP-mediated efflux of pantoprazole.
What to do
No routine adjustment is needed. Reduce the pantoprazole dose if adverse effects appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pantoprazole
- Pantoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Pantoprazole Major
- Atazanavir + Pantoprazole Major
- Dacomitinib + Pantoprazole Major
- Dasatinib + Pantoprazole Major
- Erlotinib + Pantoprazole Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Pantoprazole with Stiripentol?
MediHelp rates the interaction as minor. Pantoprazole and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Stiripentol inhibits CYP2C19 and BCRP, both involved in pantoprazole disposition, so pantoprazole exposure may increase. Clinical consequences are probably limited.
How serious is the interaction between Pantoprazole and Stiripentol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Reduce the pantoprazole dose if adverse effects appear.
What other medicines interact with Pantoprazole?
MediHelp also lists interactions of Pantoprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Pantoprazole page.
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