Drug interactions
Pantoprazole + Vadadustat
Severity: Minor
Pantoprazole and Vadadustat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vadadustat inhibits BCRP and may increase pantoprazole exposure. The clinical effect is likely small because pantoprazole has a wide safety margin.
What this interaction means in plain words
Pantoprazole and Vadadustat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pantoprazole belongs to Gastrointestinal Tract; Vadadustat belongs to Endocrine.
Why it happens
Inhibition of intestinal BCRP efflux of pantoprazole by vadadustat.
What to do
No routine adjustment is required. Monitor for pantoprazole adverse effects and reduce the dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pantoprazole
- Pantoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Pantoprazole Major
- Atazanavir + Pantoprazole Major
- Dacomitinib + Pantoprazole Major
- Dasatinib + Pantoprazole Major
- Erlotinib + Pantoprazole Major
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Frequently asked questions
Can I take Pantoprazole with Vadadustat?
MediHelp rates the interaction as minor. Pantoprazole and Vadadustat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vadadustat inhibits BCRP and may increase pantoprazole exposure. The clinical effect is likely small because pantoprazole has a wide safety margin.
How serious is the interaction between Pantoprazole and Vadadustat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is required. Monitor for pantoprazole adverse effects and reduce the dose if they occur.
What other medicines interact with Pantoprazole?
MediHelp also lists interactions of Pantoprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Pantoprazole page.
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