Drug interactions
Papaveretum + Propofol
Severity: Major
Papaveretum and Propofol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Papaveretum contains opium alkaloids including morphine, and with propofol it causes additive sedation, respiratory depression and hypotension. Apnea and airway obstruction are more likely.
What this interaction means in plain words
Papaveretum and Propofol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression from opioid mu-receptor agonism and propofol GABA-A potentiation.
What to do
Reduce the propofol dose and titrate slowly, with continuous respiratory and hemodynamic monitoring. Keep airway equipment and naloxone available.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Propofol
Frequently asked questions
Can I take Papaveretum with Propofol?
MediHelp rates the interaction as major. Papaveretum and Propofol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Papaveretum contains opium alkaloids including morphine, and with propofol it causes additive sedation, respiratory depression and hypotension. Apnea and airway obstruction are more likely.
How serious is the interaction between Papaveretum and Propofol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the propofol dose and titrate slowly, with continuous respiratory and hemodynamic monitoring. Keep airway equipment and naloxone available.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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