Drug interactions
Papaverine + Quetiapine
Severity: Minor
Papaverine and Quetiapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Papaverine is a vasodilator with possible mild CNS depressant effects, and quetiapine causes sedation and orthostatic hypotension. Combined use could add to dizziness and low blood pressure, though evidence is sparse.
What this interaction means in plain words
Papaverine and Quetiapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Papaverine belongs to Cardiovascular; Quetiapine belongs to Central Nervous System.
Why it happens
Possible additive sedative and vasodilatory or hypotensive effects; not well characterized.
What to do
Monitor for dizziness, sedation and orthostatic hypotension, and counsel on rising slowly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Papaverine
- Givinostat + Papaverine Major
- Bretylium + Papaverine Moderate
- Calcium / magnesium / potassium / sodium oxybates + Papaverine Moderate
- Carbidopa-entacapone-levodopa + Papaverine Moderate
- Carbidopa-levodopa + Papaverine Moderate
- Carbidopa + Papaverine Moderate
Frequently asked questions
Can I take Papaverine with Quetiapine?
MediHelp rates the interaction as minor. Papaverine and Quetiapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Papaverine is a vasodilator with possible mild CNS depressant effects, and quetiapine causes sedation and orthostatic hypotension. Combined use could add to dizziness and low blood pressure, though evidence is sparse.
How serious is the interaction between Papaverine and Quetiapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, sedation and orthostatic hypotension, and counsel on rising slowly.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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