Drug interactions
Papaverine + Sufentanil
Severity: Moderate
Papaverine and Sufentanil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sufentanil is a very potent opioid that causes dose-related sedation and respiratory depression. Papaverine adds little CNS depression itself, but the combined effect on alertness and blood pressure may be somewhat greater, and the opioid's risks dominate.
What this interaction means in plain words
Papaverine and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Papaverine belongs to Cardiovascular; Sufentanil belongs to Musculoskeletal.
Why it happens
Possible additive CNS depression and vasodilatory hypotension on top of sufentanil's opioid effects.
What to do
Monitor sedation level, respiratory rate and blood pressure, and titrate sufentanil to effect. Ensure appropriate monitoring and resuscitation capability in the setting of use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Papaverine
- Givinostat + Papaverine Major
- Bretylium + Papaverine Moderate
- Calcium / magnesium / potassium / sodium oxybates + Papaverine Moderate
- Carbidopa-entacapone-levodopa + Papaverine Moderate
- Carbidopa-levodopa + Papaverine Moderate
- Carbidopa + Papaverine Moderate
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Papaverine with Sufentanil?
MediHelp rates the interaction as moderate. Papaverine and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sufentanil is a very potent opioid that causes dose-related sedation and respiratory depression. Papaverine adds little CNS depression itself, but the combined effect on alertness and blood pressure may be somewhat greater, and the opioid's risks dominate.
How serious is the interaction between Papaverine and Sufentanil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level, respiratory rate and blood pressure, and titrate sufentanil to effect. Ensure appropriate monitoring and resuscitation capability in the setting of use.
What other medicines interact with Papaverine?
MediHelp also lists interactions of Papaverine with, for example, Givinostat, Bretylium, Calcium / magnesium / potassium / sodium oxybates. The full list is on the Papaverine page.
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