Drug interactions
Paracetamol + Pretomanid
Severity: Moderate
Paracetamol and Pretomanid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The pretomanid-containing regimen is associated with hepatotoxicity, and labeling advises avoiding other hepatotoxic agents. Paracetamol can cause dose-related liver injury, so combined use may add to the risk.
What this interaction means in plain words
Paracetamol and Pretomanid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paracetamol belongs to Musculoskeletal; Pretomanid belongs to Anti Bacterial.
Why it happens
Additive hepatotoxicity; no pharmacokinetic mechanism is established.
What to do
Use the lowest effective paracetamol dose for the shortest time and monitor liver enzymes regularly during the regimen. Avoid alcohol and interrupt treatment if hepatotoxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paracetamol
- Ethanol + Paracetamol Major
- Busulfan + Paracetamol Moderate
- Carbamazepine + Paracetamol Moderate
- Cholestyramine + Paracetamol Moderate
- Felbamate + Paracetamol Moderate
- Fosphenytoin + Paracetamol Moderate
Other interactions of Pretomanid
Frequently asked questions
Can I take Paracetamol with Pretomanid?
MediHelp rates the interaction as moderate. Paracetamol and Pretomanid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The pretomanid-containing regimen is associated with hepatotoxicity, and labeling advises avoiding other hepatotoxic agents. Paracetamol can cause dose-related liver injury, so combined use may add to the risk.
How serious is the interaction between Paracetamol and Pretomanid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective paracetamol dose for the shortest time and monitor liver enzymes regularly during the regimen. Avoid alcohol and interrupt treatment if hepatotoxicity develops.
What other medicines interact with Paracetamol?
MediHelp also lists interactions of Paracetamol with, for example, Ethanol, Busulfan, Carbamazepine. The full list is on the Paracetamol page.
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