Drug interactions
Parecoxib + Prochlorperazine
Severity: Minor
Parecoxib and Prochlorperazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
A CYP2D6 interaction is suggested in which parecoxib might raise prochlorperazine levels. This is weakly supported and unlikely to be clinically significant.
What this interaction means in plain words
Parecoxib and Prochlorperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible minor CYP2D6 inhibition; not well established.
What to do
No specific action is required; monitor for excess sedation or extrapyramidal effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Parecoxib with Prochlorperazine?
MediHelp rates the interaction as minor. Parecoxib and Prochlorperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. A CYP2D6 interaction is suggested in which parecoxib might raise prochlorperazine levels. This is weakly supported and unlikely to be clinically significant.
How serious is the interaction between Parecoxib and Prochlorperazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is required; monitor for excess sedation or extrapyramidal effects.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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