Drug interactions
Parecoxib + Ticlopidine
Severity: Moderate
Parecoxib and Ticlopidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parecoxib is converted to valdecoxib, which is cleared by CYP3A4 and CYP2C9. Ticlopidine's CYP2C19 inhibition has no clear effect on this pathway, though both drugs may add to gastrointestinal bleeding risk.
What this interaction means in plain words
Parecoxib and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on bleeding: antiplatelet action of ticlopidine plus NSAID-related gastric mucosal injury and platelet effects.
What to do
Monitor for gastrointestinal bleeding and bruising. Use the lowest effective parecoxib dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ticlopidine
Frequently asked questions
Can I take Parecoxib with Ticlopidine?
MediHelp rates the interaction as moderate. Parecoxib and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Parecoxib is converted to valdecoxib, which is cleared by CYP3A4 and CYP2C9. Ticlopidine's CYP2C19 inhibition has no clear effect on this pathway, though both drugs may add to gastrointestinal bleeding risk.
How serious is the interaction between Parecoxib and Ticlopidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for gastrointestinal bleeding and bruising. Use the lowest effective parecoxib dose for the shortest time.
What other medicines interact with Ticlopidine?
MediHelp also lists interactions of Ticlopidine with, for example, Mavacamten, Abrocitinib, Acetylsalicylic acid. The full list is on the Ticlopidine page.
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