Drug interactions
Paricalcitol + Ribociclib
Severity: Minor
Paricalcitol and Ribociclib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a moderate CYP3A4 inhibitor and may raise paricalcitol exposure, since paricalcitol is partly metabolized by CYP3A4. Higher paricalcitol levels could increase the risk of hypercalcemia and hypercalciuria.
What this interaction means in plain words
Paricalcitol and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Paricalcitol belongs to Musculoskeletal; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4, which reduces the metabolic clearance of paricalcitol.
What to do
Monitor serum calcium, phosphorus and PTH after starting ribociclib and adjust the paricalcitol dose if hypercalcemia develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Paricalcitol
- Carbamazepine + Paricalcitol Moderate
- Cholestyramine + Paricalcitol Moderate
- Clarithromycin + Paricalcitol Moderate
- Digoxin + Paricalcitol Moderate
- Ketoconazole + Paricalcitol Moderate
- Paricalcitol + Posaconazole Moderate
Frequently asked questions
Can I take Paricalcitol with Ribociclib?
MediHelp rates the interaction as minor. Paricalcitol and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ribociclib is a moderate CYP3A4 inhibitor and may raise paricalcitol exposure, since paricalcitol is partly metabolized by CYP3A4. Higher paricalcitol levels could increase the risk of hypercalcemia and hypercalciuria.
How serious is the interaction between Paricalcitol and Ribociclib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium, phosphorus and PTH after starting ribociclib and adjust the paricalcitol dose if hypercalcemia develops.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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