Drug interactions
Paromomycin + Rocuronium
Severity: Moderate
Paromomycin and Rocuronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral paromomycin is minimally absorbed, but systemic uptake can occur with damaged gut mucosa or renal impairment. In that case, aminoglycoside effects may potentiate rocuronium and prolong paralysis.
What this interaction means in plain words
Paromomycin and Rocuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paromomycin belongs to Anti Bacterial; Rocuronium belongs to Musculoskeletal.
Why it happens
Aminoglycoside-mediated impairment of neuromuscular transmission adding to non-depolarizing blockade.
What to do
Monitor neuromuscular function with train-of-four, especially with intestinal ulceration or renal impairment. Titrate rocuronium and ensure ventilatory support.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rocuronium
Other interactions of Paromomycin
- Cidofovir + Paromomycin Major
- Adefovir + Paromomycin Moderate
- Amikacin + Paromomycin Moderate
- Amphotericin b + Paromomycin Moderate
- Atracurium + Paromomycin Moderate
- Bacitracin-neomycin-polymyxin + Paromomycin Moderate
Frequently asked questions
Can I take Paromomycin with Rocuronium?
MediHelp rates the interaction as moderate. Paromomycin and Rocuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral paromomycin is minimally absorbed, but systemic uptake can occur with damaged gut mucosa or renal impairment. In that case, aminoglycoside effects may potentiate rocuronium and prolong paralysis.
How serious is the interaction between Paromomycin and Rocuronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with train-of-four, especially with intestinal ulceration or renal impairment. Titrate rocuronium and ensure ventilatory support.
What other medicines interact with Rocuronium?
MediHelp also lists interactions of Rocuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Rocuronium page.
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