Drug interactions
Paromomycin + Streptomycin
Severity: Moderate
Paromomycin and Streptomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are aminoglycosides, and although oral paromomycin is poorly absorbed, systemic exposure can increase in patients with renal impairment or damaged bowel mucosa. In that setting the combination adds to the kidney, hearing and balance toxicity of streptomycin.
What this interaction means in plain words
Paromomycin and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paromomycin belongs to Anti Bacterial; Streptomycin belongs to Anti Bacterial.
Why it happens
Additive aminoglycoside nephrotoxicity and ototoxicity when paromomycin is absorbed systemically.
What to do
Monitor renal function and hearing in patients with renal impairment or intestinal ulceration receiving both, and avoid the combination if an alternative exists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Streptomycin
Other interactions of Paromomycin
- Cidofovir + Paromomycin Major
- Adefovir + Paromomycin Moderate
- Amikacin + Paromomycin Moderate
- Amphotericin b + Paromomycin Moderate
- Atracurium + Paromomycin Moderate
- Bacitracin-neomycin-polymyxin + Paromomycin Moderate
Frequently asked questions
Can I take Paromomycin with Streptomycin?
MediHelp rates the interaction as moderate. Paromomycin and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are aminoglycosides, and although oral paromomycin is poorly absorbed, systemic exposure can increase in patients with renal impairment or damaged bowel mucosa. In that setting the combination adds to the kidney, hearing and balance toxicity of streptomycin.
How serious is the interaction between Paromomycin and Streptomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and hearing in patients with renal impairment or intestinal ulceration receiving both, and avoid the combination if an alternative exists.
What other medicines interact with Streptomycin?
MediHelp also lists interactions of Streptomycin with, for example, Abobotulinumtoxina, Adefovir, Amikacin. The full list is on the Streptomycin page.
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