Drug interactions
Paromomycin + Tolmetin
Severity: Minor
Paromomycin and Tolmetin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral paromomycin is minimally absorbed, so systemic interaction is unlikely in most patients. Reduced aminoglycoside clearance with NSAIDs has been noted mainly in preterm infants.
What this interaction means in plain words
Paromomycin and Tolmetin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Paromomycin belongs to Anti Bacterial; Tolmetin belongs to Musculoskeletal.
Why it happens
NSAID-induced reduction in renal clearance of absorbed aminoglycoside.
What to do
No action is typically needed; in neonates or renal impairment, monitor renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Other interactions of Paromomycin
- Cidofovir + Paromomycin Major
- Adefovir + Paromomycin Moderate
- Amikacin + Paromomycin Moderate
- Amphotericin b + Paromomycin Moderate
- Atracurium + Paromomycin Moderate
- Bacitracin-neomycin-polymyxin + Paromomycin Moderate
Frequently asked questions
Can I take Paromomycin with Tolmetin?
MediHelp rates the interaction as minor. Paromomycin and Tolmetin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral paromomycin is minimally absorbed, so systemic interaction is unlikely in most patients. Reduced aminoglycoside clearance with NSAIDs has been noted mainly in preterm infants.
How serious is the interaction between Paromomycin and Tolmetin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is typically needed; in neonates or renal impairment, monitor renal function.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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