Drug interactions
Paroxetine + Pregabalin
Severity: Minor
Paroxetine and Pregabalin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can cause drowsiness and dizziness, and together may increase sedation and impaired coordination. Respiratory depression is unlikely unless other CNS depressants are also involved.
What this interaction means in plain words
Paroxetine and Pregabalin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Paroxetine belongs to Central Nervous System; Pregabalin belongs to Central Nervous System.
Why it happens
Additive central nervous system depressant effects.
What to do
Start pregabalin at a low dose and monitor for sedation and dizziness. Advise caution when driving or operating machinery.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Other interactions of Pregabalin
Frequently asked questions
Can I take Paroxetine with Pregabalin?
MediHelp rates the interaction as minor. Paroxetine and Pregabalin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both agents can cause drowsiness and dizziness, and together may increase sedation and impaired coordination. Respiratory depression is unlikely unless other CNS depressants are also involved.
How serious is the interaction between Paroxetine and Pregabalin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start pregabalin at a low dose and monitor for sedation and dizziness. Advise caution when driving or operating machinery.
What other medicines interact with Paroxetine?
MediHelp also lists interactions of Paroxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Paroxetine page.
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