Drug interactions
Paroxetine + Ranolazine
Severity: Moderate
Paroxetine and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paroxetine is a strong CYP2D6 inhibitor, and ranolazine is partly metabolized by CYP2D6, so ranolazine levels can rise modestly. Ranolazine prolongs QTc in a dose-related way, so higher exposure may add to arrhythmia risk.
What this interaction means in plain words
Paroxetine and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paroxetine belongs to Central Nervous System; Ranolazine belongs to Cardiovascular.
Why it happens
CYP2D6 inhibition by paroxetine raises ranolazine exposure, with a possible small additive effect on QT interval.
What to do
Monitor ECG for QTc prolongation and watch for ranolazine adverse effects such as dizziness and nausea. Use the lowest effective ranolazine dose and correct electrolyte disturbances.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Paroxetine with Ranolazine?
MediHelp rates the interaction as moderate. Paroxetine and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paroxetine is a strong CYP2D6 inhibitor, and ranolazine is partly metabolized by CYP2D6, so ranolazine levels can rise modestly. Ranolazine prolongs QTc in a dose-related way, so higher exposure may add to arrhythmia risk.
How serious is the interaction between Paroxetine and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG for QTc prolongation and watch for ranolazine adverse effects such as dizziness and nausea. Use the lowest effective ranolazine dose and correct electrolyte disturbances.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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