Drug interactions
Paroxetine + Sotalol
Severity: Moderate
Paroxetine and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs may influence QTc, although paroxetine has a low QT liability. Paroxetine strongly inhibits CYP2D6 and may increase bradycardia risk with beta-blockers.
What this interaction means in plain words
Paroxetine and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paroxetine belongs to Central Nervous System; Sotalol belongs to Cardiovascular.
Why it happens
Possible additive QT prolongation and pharmacodynamic bradycardia; CYP2D6 inhibition is of limited relevance for sotalol, which is renally cleared.
What to do
Obtain a baseline ECG and monitor heart rate and QTc after starting paroxetine. Correct electrolytes and consider another agent if QTc rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Paroxetine with Sotalol?
MediHelp rates the interaction as moderate. Paroxetine and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs may influence QTc, although paroxetine has a low QT liability. Paroxetine strongly inhibits CYP2D6 and may increase bradycardia risk with beta-blockers.
How serious is the interaction between Paroxetine and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor heart rate and QTc after starting paroxetine. Correct electrolytes and consider another agent if QTc rises.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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