Drug interactions
Paroxetine + Tedizolid
Severity: Major
Paroxetine and Tedizolid: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paroxetine is a potent serotonin reuptake inhibitor, and tedizolid is a weak reversible MAO inhibitor. Serotonin syndrome is a theoretical concern because the oxazolidinone class is linked to such cases. Trial data with tedizolid showed few such events, but exposure to SSRIs was limited.
What this interaction means in plain words
Paroxetine and Tedizolid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Paroxetine belongs to Central Nervous System; Tedizolid belongs to Anti Bacterial.
Why it happens
Additive serotonergic effects from SSRI reuptake blockade and weak MAO inhibition by tedizolid.
What to do
Use a non-serotonergic antibiotic when possible. If co-use is unavoidable, watch for agitation, tremor, clonus, sweating and fever, and stop one drug if serotonin syndrome is suspected.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Paroxetine and Tedizolid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Tedizolid
- Bupropion + Tedizolid Major
- Cyproheptadine + Tedizolid Major
- Deferiprone + Tedizolid Major
- Isocarboxazid + Tedizolid Major
- Meperidine + Tedizolid Major
- Methamphetamine + Tedizolid Major
Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Paroxetine with Tedizolid?
MediHelp rates the interaction as major. Paroxetine and Tedizolid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Paroxetine is a potent serotonin reuptake inhibitor, and tedizolid is a weak reversible MAO inhibitor. Serotonin syndrome is a theoretical concern because the oxazolidinone class is linked to such cases. Trial data with tedizolid showed few such events, but exposure to SSRIs was limited.
How serious is the interaction between Paroxetine and Tedizolid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-serotonergic antibiotic when possible. If co-use is unavoidable, watch for agitation, tremor, clonus, sweating and fever, and stop one drug if serotonin syndrome is suspected.
What other medicines interact with Tedizolid?
MediHelp also lists interactions of Tedizolid with, for example, Bupropion, Cyproheptadine, Deferiprone. The full list is on the Tedizolid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
