Drug interactions
Pasireotide + Risperidone
Severity: Moderate
Pasireotide and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pasireotide can cause bradycardia and QT prolongation, and risperidone also lengthens QT. Combined use may raise the risk of torsades de pointes.
What this interaction means in plain words
Pasireotide and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pasireotide belongs to Endocrine; Risperidone belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with bradycardia from pasireotide as an added risk.
What to do
Check a baseline ECG and correct hypokalemia and hypomagnesemia. Repeat the ECG after treatment initiation and dose changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Pasireotide
- Dronedarone + Pasireotide Contraindicated
- Pasireotide + Pimozide Contraindicated
- Amiodarone + Pasireotide Major
- Amisulpride + Pasireotide Major
- Amitriptyline + Pasireotide Major
- Anagrelide + Pasireotide Major
Frequently asked questions
Can I take Pasireotide with Risperidone?
MediHelp rates the interaction as moderate. Pasireotide and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pasireotide can cause bradycardia and QT prolongation, and risperidone also lengthens QT. Combined use may raise the risk of torsades de pointes.
How serious is the interaction between Pasireotide and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and correct hypokalemia and hypomagnesemia. Repeat the ECG after treatment initiation and dose changes.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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