Drug interactions
Pazopanib + Risperidone
Severity: Moderate
Pazopanib and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib can prolong the QT interval and risperidone adds modest QT risk, so combined use may raise arrhythmia risk.
What this interaction means in plain words
Pazopanib and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pazopanib belongs to Oncology; Risperidone belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT interval prolongation.
What to do
Check baseline ECG and electrolytes, and monitor ECG periodically during co-therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Pazopanib with Risperidone?
MediHelp rates the interaction as moderate. Pazopanib and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pazopanib can prolong the QT interval and risperidone adds modest QT risk, so combined use may raise arrhythmia risk.
How serious is the interaction between Pazopanib and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes, and monitor ECG periodically during co-therapy.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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