Drug interactions
Pazopanib + Tiotropium-olodaterol
Severity: Moderate
Pazopanib and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib can prolong the QT interval, and high doses of beta2 agonists such as olodaterol can add to cardiac repolarization effects and cause hypokalemia. Together they may raise the risk of ventricular arrhythmias, particularly in patients with cardiac disease or electrolyte disturbances.
What this interaction means in plain words
Pazopanib and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pazopanib belongs to Oncology; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive QT prolongation and beta2-mediated hypokalemia and sympathetic cardiac stimulation.
What to do
Obtain a baseline ECG and correct potassium and magnesium before starting, then repeat the ECG periodically. Avoid exceeding the recommended olodaterol dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Pazopanib with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Pazopanib and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pazopanib can prolong the QT interval, and high doses of beta2 agonists such as olodaterol can add to cardiac repolarization effects and cause hypokalemia. Together they may raise the risk of ventricular arrhythmias, particularly in patients with cardiac disease or electrolyte disturbances.
How serious is the interaction between Pazopanib and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before starting, then repeat the ECG periodically. Avoid exceeding the recommended olodaterol dose.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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