Drug interactions
Pazopanib + Trimipramine
Severity: Major
Pazopanib and Trimipramine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib is associated with QT prolongation and torsades de pointes, and trimipramine adds to this effect. The combination raises the risk of serious arrhythmia, particularly with electrolyte abnormalities or cardiac disease.
What this interaction means in plain words
Pazopanib and Trimipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pazopanib belongs to Oncology; Trimipramine belongs to Central Nervous System.
Why it happens
Additive QT prolongation; pazopanib also inhibits CYP2D6 and CYP3A4 weakly, possibly raising trimipramine levels.
What to do
Obtain a baseline ECG and electrolytes and monitor periodically during therapy. Consider an alternative antidepressant with less QT effect.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Pazopanib with Trimipramine?
MediHelp rates the interaction as major. Pazopanib and Trimipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pazopanib is associated with QT prolongation and torsades de pointes, and trimipramine adds to this effect. The combination raises the risk of serious arrhythmia, particularly with electrolyte abnormalities or cardiac disease.
How serious is the interaction between Pazopanib and Trimipramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and electrolytes and monitor periodically during therapy. Consider an alternative antidepressant with less QT effect.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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