Drug interactions
Bosentan + Peginterferon alfa 2b
Severity: Moderate
Bosentan and Peginterferon alfa 2b: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Peginterferon alfa 2b may alter CYP2C9 activity, which could change bosentan levels. The effect is poorly characterized, and both drugs can affect liver tests, which complicates monitoring.
What this interaction means in plain words
Bosentan and Peginterferon alfa 2b can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Peginterferon alfa 2b belongs to Anti Virals.
Why it happens
Possible interferon modulation of CYP2C9 (and CYP3A4) metabolism of bosentan; not firmly established.
What to do
Monitor liver enzymes monthly as required for bosentan, and watch for changes in pulmonary hypertension response. Adjust therapy if hepatotoxicity or reduced efficacy occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Peginterferon alfa 2b
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Cyclosporine Contraindicated
- Bosentan + Glyburide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
Frequently asked questions
Can I take Bosentan with Peginterferon alfa 2b?
MediHelp rates the interaction as moderate. Bosentan and Peginterferon alfa 2b can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Peginterferon alfa 2b may alter CYP2C9 activity, which could change bosentan levels. The effect is poorly characterized, and both drugs can affect liver tests, which complicates monitoring.
How serious is the interaction between Bosentan and Peginterferon alfa 2b?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes monthly as required for bosentan, and watch for changes in pulmonary hypertension response. Adjust therapy if hepatotoxicity or reduced efficacy occurs.
What other medicines interact with Peginterferon alfa 2b?
MediHelp also lists interactions of Peginterferon alfa 2b with, for example, Aldesleukin, Deferiprone, Pexidartinib. The full list is on the Peginterferon alfa 2b page.
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