Drug interactions
Peginterferon alfa 2b + Ritonavir
Severity: Moderate
Peginterferon alfa 2b and Ritonavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both peginterferon and ritonavir can cause hepatotoxicity, and peginterferon may alter CYP-mediated drug metabolism. Combined use may raise the risk of liver injury, and in HIV coinfection this needs careful follow-up.
What this interaction means in plain words
Peginterferon alfa 2b and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Peginterferon alfa 2b belongs to Anti Virals; Ritonavir belongs to Anti Virals.
Why it happens
Additive hepatotoxicity, with possible interferon-related changes in CYP activity.
What to do
Monitor liver enzymes and bilirubin regularly and reduce or stop either drug if hepatic decompensation or significant elevations occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Peginterferon alfa 2b and Ritonavir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Peginterferon alfa 2b
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Peginterferon alfa 2b with Ritonavir?
MediHelp rates the interaction as moderate. Peginterferon alfa 2b and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both peginterferon and ritonavir can cause hepatotoxicity, and peginterferon may alter CYP-mediated drug metabolism. Combined use may raise the risk of liver injury, and in HIV coinfection this needs careful follow-up.
How serious is the interaction between Peginterferon alfa 2b and Ritonavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and bilirubin regularly and reduce or stop either drug if hepatic decompensation or significant elevations occur.
What other medicines interact with Peginterferon alfa 2b?
MediHelp also lists interactions of Peginterferon alfa 2b with, for example, Aldesleukin, Deferiprone, Pexidartinib. The full list is on the Peginterferon alfa 2b page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
