Drug interactions
Peginterferon alfa 2b + Zafirlukast
Severity: Minor
Peginterferon alfa 2b and Zafirlukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Interferons can suppress some hepatic cytochrome P450 activity, which might alter zafirlukast clearance. The effect is poorly characterized and unlikely to be of major clinical consequence.
What this interaction means in plain words
Peginterferon alfa 2b and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Peginterferon alfa 2b belongs to Anti Virals; Zafirlukast belongs to Respiratory.
Why it happens
Cytokine-mediated modulation of hepatic CYP enzymes by peginterferon; the exact effect on zafirlukast is not well established.
What to do
Monitor asthma control and zafirlukast tolerability, including liver tests, during peginterferon therapy. No empirical dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Peginterferon alfa 2b
Frequently asked questions
Can I take Peginterferon alfa 2b with Zafirlukast?
MediHelp rates the interaction as minor. Peginterferon alfa 2b and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Interferons can suppress some hepatic cytochrome P450 activity, which might alter zafirlukast clearance. The effect is poorly characterized and unlikely to be of major clinical consequence.
How serious is the interaction between Peginterferon alfa 2b and Zafirlukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor asthma control and zafirlukast tolerability, including liver tests, during peginterferon therapy. No empirical dose change is needed.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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