Drug interactions
Pegvisomant + Pioglitazone
Severity: Moderate
Pegvisomant and Pioglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pegvisomant blocks growth hormone action and improves insulin sensitivity, which can lower glucose in diabetic patients. Combined with pioglitazone, glucose-lowering may be enhanced and hypoglycemia can occur.
What this interaction means in plain words
Pegvisomant and Pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pegvisomant belongs to Endocrine; Pioglitazone belongs to Endocrine.
Why it happens
Growth hormone receptor antagonism reduces insulin resistance, adding to the insulin-sensitizing effect of pioglitazone.
What to do
Monitor blood glucose when starting or adjusting pegvisomant and reduce pioglitazone or other antidiabetic doses if glucose falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pioglitazone
Other interactions of Pegvisomant
- Alogliptin-metformin + Pegvisomant Moderate
- Alogliptin-pioglitazone + Pegvisomant Moderate
- Chlorpropamide + Pegvisomant Moderate
- Codeine + Pegvisomant Moderate
- Dapagliflozin-metformin + Pegvisomant Moderate
- Ertugliflozin-sitagliptin + Pegvisomant Moderate
Frequently asked questions
Can I take Pegvisomant with Pioglitazone?
MediHelp rates the interaction as moderate. Pegvisomant and Pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pegvisomant blocks growth hormone action and improves insulin sensitivity, which can lower glucose in diabetic patients. Combined with pioglitazone, glucose-lowering may be enhanced and hypoglycemia can occur.
How serious is the interaction between Pegvisomant and Pioglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or adjusting pegvisomant and reduce pioglitazone or other antidiabetic doses if glucose falls.
What other medicines interact with Pioglitazone?
MediHelp also lists interactions of Pioglitazone with, for example, Insulin aspart-insulin aspart protamine, Insulin aspart, Insulin degludec-insulin aspart. The full list is on the Pioglitazone page.
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