Drug interactions
Pemetrexed + Trastuzumab deruxtecan
Severity: Moderate
Pemetrexed and Trastuzumab deruxtecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents cause myelosuppression, and neutropenia is a common toxicity of trastuzumab deruxtecan. Combining them may increase the incidence and severity of neutropenia and infection.
What this interaction means in plain words
Pemetrexed and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pemetrexed belongs to Oncology; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive bone marrow suppression.
What to do
Monitor complete blood counts regularly and adjust doses or delay treatment for significant neutropenia. Counsel patients to report fever promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pemetrexed
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Pemetrexed with Trastuzumab deruxtecan?
MediHelp rates the interaction as moderate. Pemetrexed and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents cause myelosuppression, and neutropenia is a common toxicity of trastuzumab deruxtecan. Combining them may increase the incidence and severity of neutropenia and infection.
How serious is the interaction between Pemetrexed and Trastuzumab deruxtecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly and adjust doses or delay treatment for significant neutropenia. Counsel patients to report fever promptly.
What other medicines interact with Pemetrexed?
MediHelp also lists interactions of Pemetrexed with, for example, Bacitracin, Brexucabtagene autoleucel, Celecoxib. The full list is on the Pemetrexed page.
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