Drug interactions
Pemigatinib + Voriconazole
Severity: Major
Pemigatinib and Voriconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole increases pemigatinib exposure, which may worsen hyperphosphatemia, ocular toxicity and other adverse effects.
What this interaction means in plain words
Pemigatinib and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pemigatinib belongs to Oncology; Voriconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 inhibition by voriconazole decreases pemigatinib metabolism.
What to do
Prefer a non-CYP3A4-inhibiting antifungal. If unavoidable, reduce the pemigatinib dose per labeling and monitor for toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Pemigatinib
Frequently asked questions
Can I take Pemigatinib with Voriconazole?
MediHelp rates the interaction as major. Pemigatinib and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voriconazole increases pemigatinib exposure, which may worsen hyperphosphatemia, ocular toxicity and other adverse effects.
How serious is the interaction between Pemigatinib and Voriconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-CYP3A4-inhibiting antifungal. If unavoidable, reduce the pemigatinib dose per labeling and monitor for toxicity.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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