Drug interactions
Penbutolol + Propofol
Severity: Moderate
Penbutolol and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propofol causes vasodilation and myocardial depression, and a beta-blocker can blunt compensatory heart rate and contractility responses. This may produce more pronounced hypotension and bradycardia.
What this interaction means in plain words
Penbutolol and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hemodynamic effects: propofol vasodilation and negative inotropy plus beta-adrenergic blockade.
What to do
Titrate propofol slowly and monitor blood pressure and heart rate continuously. Have fluids and vasopressors or atropine available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propofol
Frequently asked questions
Can I take Penbutolol with Propofol?
MediHelp rates the interaction as moderate. Penbutolol and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propofol causes vasodilation and myocardial depression, and a beta-blocker can blunt compensatory heart rate and contractility responses. This may produce more pronounced hypotension and bradycardia.
How serious is the interaction between Penbutolol and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol slowly and monitor blood pressure and heart rate continuously. Have fluids and vasopressors or atropine available.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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