Drug interactions
Pentamidine + Tenofovir disoproxil
Severity: Moderate
Pentamidine and Tenofovir disoproxil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic pentamidine is nephrotoxic, and tenofovir can cause proximal tubular injury. Combined use raises the risk of acute kidney injury and electrolyte disturbances.
What this interaction means in plain words
Pentamidine and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity affecting renal tubular cells.
What to do
Monitor serum creatinine, electrolytes and phosphate frequently during pentamidine therapy, and consider an alternative to tenofovir for the duration if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pentamidine
- Clomipramine + Pentamidine Contraindicated
- Desipramine + Pentamidine Contraindicated
- Dronedarone + Pentamidine Contraindicated
- Moxifloxacin + Pentamidine Contraindicated
- Nortriptyline + Pentamidine Contraindicated
- Pentamidine + Pimozide Contraindicated
Frequently asked questions
Can I take Pentamidine with Tenofovir disoproxil?
MediHelp rates the interaction as moderate. Pentamidine and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic pentamidine is nephrotoxic, and tenofovir can cause proximal tubular injury. Combined use raises the risk of acute kidney injury and electrolyte disturbances.
How serious is the interaction between Pentamidine and Tenofovir disoproxil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, electrolytes and phosphate frequently during pentamidine therapy, and consider an alternative to tenofovir for the duration if renal function declines.
What other medicines interact with Pentamidine?
MediHelp also lists interactions of Pentamidine with, for example, Clomipramine, Desipramine, Dronedarone. The full list is on the Pentamidine page.
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