Drug interactions
Pentobarbital + Posaconazole
Severity: Moderate
Pentobarbital and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentobarbital may lower posaconazole concentrations, risking reduced antifungal efficacy, particularly with repeated dosing.
What this interaction means in plain words
Pentobarbital and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate-mediated induction of UGT and efflux transport, lowering posaconazole exposure.
What to do
Avoid prolonged coadministration where possible and monitor posaconazole trough concentrations and clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Pentobarbital with Posaconazole?
MediHelp rates the interaction as moderate. Pentobarbital and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pentobarbital may lower posaconazole concentrations, risking reduced antifungal efficacy, particularly with repeated dosing.
How serious is the interaction between Pentobarbital and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid prolonged coadministration where possible and monitor posaconazole trough concentrations and clinical response.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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