Drug interactions
Pentobarbital + Prochlorperazine
Severity: Major
Pentobarbital and Prochlorperazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentobarbital is a potent sedative-hypnotic and prochlorperazine adds further CNS depression and hypotension. Excess sedation and respiratory depression may occur. Barbiturates can also induce metabolism of phenothiazines and reduce their effect.
What this interaction means in plain words
Pentobarbital and Prochlorperazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS depression; barbiturate induction of hepatic enzymes may lower prochlorperazine exposure.
What to do
Monitor sedation, respiratory status and blood pressure, and lower doses as needed. Reassess antiemetic or antipsychotic efficacy during prolonged barbiturate use.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Pentobarbital with Prochlorperazine?
MediHelp rates the interaction as major. Pentobarbital and Prochlorperazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pentobarbital is a potent sedative-hypnotic and prochlorperazine adds further CNS depression and hypotension. Excess sedation and respiratory depression may occur. Barbiturates can also induce metabolism of phenothiazines and reduce their effect.
How serious is the interaction between Pentobarbital and Prochlorperazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, respiratory status and blood pressure, and lower doses as needed. Reassess antiemetic or antipsychotic efficacy during prolonged barbiturate use.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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