Drug interactions
Perphenazine + Procarbazine
Severity: Moderate
Perphenazine and Procarbazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine is a weak monoamine oxidase inhibitor and may add to the sedation of perphenazine. Serotonergic and dopaminergic interplay could theoretically increase the risk of serotonin syndrome or neuroleptic malignant syndrome.
What this interaction means in plain words
Perphenazine and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Perphenazine belongs to Central Nervous System; Procarbazine belongs to Oncology.
Why it happens
Additive CNS depression plus MAO inhibition altering monoamine tone, with an uncertain clinical contribution.
What to do
Monitor for excessive sedation, hyperthermia, rigidity, agitation and autonomic instability. Reduce perphenazine dose if oversedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Perphenazine and Procarbazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Perphenazine with Procarbazine?
MediHelp rates the interaction as moderate. Perphenazine and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine is a weak monoamine oxidase inhibitor and may add to the sedation of perphenazine. Serotonergic and dopaminergic interplay could theoretically increase the risk of serotonin syndrome or neuroleptic malignant syndrome.
How serious is the interaction between Perphenazine and Procarbazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, hyperthermia, rigidity, agitation and autonomic instability. Reduce perphenazine dose if oversedation occurs.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
