Drug interactions
Perphenazine + Propafenone
Severity: Moderate
Perphenazine and Propafenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine is both a CYP2D6 substrate and inhibitor, and propafenone is also a CYP2D6 substrate and inhibitor, so each may raise the other's concentrations. Higher propafenone levels increase the risk of conduction disturbance and arrhythmia, while higher perphenazine levels increase extrapyramidal effects and sedation.
What this interaction means in plain words
Perphenazine and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Perphenazine belongs to Central Nervous System; Propafenone belongs to Cardiovascular.
Why it happens
Mutual competitive inhibition of CYP2D6-mediated metabolism, with additive cardiac effects.
What to do
Monitor ECG, heart rate and extrapyramidal symptoms, and adjust the dose of either drug if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Perphenazine and Propafenone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Perphenazine with Propafenone?
MediHelp rates the interaction as moderate. Perphenazine and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perphenazine is both a CYP2D6 substrate and inhibitor, and propafenone is also a CYP2D6 substrate and inhibitor, so each may raise the other's concentrations. Higher propafenone levels increase the risk of conduction disturbance and arrhythmia, while higher perphenazine levels increase extrapyramidal effects and sedation.
How serious is the interaction between Perphenazine and Propafenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, heart rate and extrapyramidal symptoms, and adjust the dose of either drug if adverse effects emerge.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
