Drug interactions
Perphenazine + Quetiapine
Severity: Moderate
Perphenazine and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent use of two antipsychotics increases total dopamine blockade, which can lead to extrapyramidal symptoms and rarely neuroleptic malignant syndrome. Sedation and orthostatic hypotension are additive, and both drugs may prolong QT.
What this interaction means in plain words
Perphenazine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Perphenazine belongs to Central Nervous System; Quetiapine belongs to Central Nervous System.
Why it happens
Additive D2 receptor antagonism and antihistaminic and alpha-adrenergic blocking effects.
What to do
Use the lowest effective doses and reassess the need for two antipsychotics. Monitor for sedation, movement disorders, orthostasis and QTc where risk factors exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Perphenazine with Quetiapine?
MediHelp rates the interaction as moderate. Perphenazine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent use of two antipsychotics increases total dopamine blockade, which can lead to extrapyramidal symptoms and rarely neuroleptic malignant syndrome. Sedation and orthostatic hypotension are additive, and both drugs may prolong QT.
How serious is the interaction between Perphenazine and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and reassess the need for two antipsychotics. Monitor for sedation, movement disorders, orthostasis and QTc where risk factors exist.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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