Drug interactions
Perphenazine + Ritonavir
Severity: Moderate
Perphenazine and Ritonavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir inhibits CYP2D6 and CYP3A4, which can raise perphenazine exposure. Higher levels may cause increased sedation, extrapyramidal symptoms, hypotension and QT prolongation.
What this interaction means in plain words
Perphenazine and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Perphenazine belongs to Central Nervous System; Ritonavir belongs to Anti Virals.
Why it happens
Ritonavir inhibition of CYP2D6 (and CYP3A4) reduces the metabolic clearance of perphenazine.
What to do
Start perphenazine at a reduced dose and titrate to response, monitoring for extrapyramidal symptoms, sedation and ECG changes. Consider an ECG if other QT-prolonging drugs are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Perphenazine with Ritonavir?
MediHelp rates the interaction as moderate. Perphenazine and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir inhibits CYP2D6 and CYP3A4, which can raise perphenazine exposure. Higher levels may cause increased sedation, extrapyramidal symptoms, hypotension and QT prolongation.
How serious is the interaction between Perphenazine and Ritonavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start perphenazine at a reduced dose and titrate to response, monitoring for extrapyramidal symptoms, sedation and ECG changes. Consider an ECG if other QT-prolonging drugs are present.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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