Drug interactions
Perphenazine + Saxagliptin-metformin
Severity: Minor
Perphenazine and Saxagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazine antipsychotics can impair glucose tolerance and cause hyperglycemia in some patients. Perphenazine carries a lower metabolic risk than some atypical agents, so the effect on saxagliptin-metformin is usually modest.
What this interaction means in plain words
Perphenazine and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Perphenazine belongs to Central Nervous System; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism, as phenothiazines may reduce insulin secretion and sensitivity.
What to do
Monitor blood glucose when perphenazine is started or changed and adjust antidiabetic therapy if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Perphenazine and Saxagliptin-metformin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Saxagliptin-metformin
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Perphenazine with Saxagliptin-metformin?
MediHelp rates the interaction as minor. Perphenazine and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenothiazine antipsychotics can impair glucose tolerance and cause hyperglycemia in some patients. Perphenazine carries a lower metabolic risk than some atypical agents, so the effect on saxagliptin-metformin is usually modest.
How serious is the interaction between Perphenazine and Saxagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when perphenazine is started or changed and adjust antidiabetic therapy if control worsens.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
