Drug interactions
Perphenazine + Sertraline
Severity: Moderate
Perphenazine and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine is metabolized by CYP2D6, which sertraline inhibits, so perphenazine levels may rise. Both drugs can also prolong the QT interval, increasing the risk of extrapyramidal effects and arrhythmia.
What this interaction means in plain words
Perphenazine and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Perphenazine belongs to Central Nervous System; Sertraline belongs to Central Nervous System.
Why it happens
CYP2D6 inhibition by sertraline and additive QT prolongation.
What to do
Start with a low perphenazine dose and monitor for extrapyramidal symptoms and sedation. Check ECG in patients with additional QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Perphenazine with Sertraline?
MediHelp rates the interaction as moderate. Perphenazine and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perphenazine is metabolized by CYP2D6, which sertraline inhibits, so perphenazine levels may rise. Both drugs can also prolong the QT interval, increasing the risk of extrapyramidal effects and arrhythmia.
How serious is the interaction between Perphenazine and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with a low perphenazine dose and monitor for extrapyramidal symptoms and sedation. Check ECG in patients with additional QT risk factors.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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