Drug interactions
Perphenazine + Sumatriptan
Severity: Minor
Perphenazine and Sumatriptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antipsychotics combined with triptans have been theoretically associated with serotonin syndrome, although cases are rare. The clinical risk is generally low.
What this interaction means in plain words
Perphenazine and Sumatriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Perphenazine belongs to Central Nervous System; Sumatriptan belongs to Central Nervous System.
Why it happens
Possible additive serotonergic effects; mechanism not well established.
What to do
No routine change is needed; advise patients to report agitation, fever, tremor or rigidity. Stop sumatriptan if serotonin toxicity is suspected.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Sumatriptan
- Almotriptan + Sumatriptan Contraindicated
- Dihydroergotamine intranasal + Sumatriptan Contraindicated
- Dihydroergotamine + Sumatriptan Contraindicated
- Eletriptan + Sumatriptan Contraindicated
- Ergoloid mesylates + Sumatriptan Contraindicated
- Ergotamine + Sumatriptan Contraindicated
Frequently asked questions
Can I take Perphenazine with Sumatriptan?
MediHelp rates the interaction as minor. Perphenazine and Sumatriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antipsychotics combined with triptans have been theoretically associated with serotonin syndrome, although cases are rare. The clinical risk is generally low.
How serious is the interaction between Perphenazine and Sumatriptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; advise patients to report agitation, fever, tremor or rigidity. Stop sumatriptan if serotonin toxicity is suspected.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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