Drug interactions
Perphenazine + Tiotropium
Severity: Minor
Perphenazine and Tiotropium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine has weak to moderate anticholinergic activity that may add to the antimuscarinic effects of tiotropium. Dry mouth, constipation and urinary retention may be more frequent.
What this interaction means in plain words
Perphenazine and Tiotropium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Perphenazine belongs to Central Nervous System; Tiotropium belongs to Respiratory.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Monitor for anticholinergic symptoms, especially in older patients or those with glaucoma or urinary retention.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tiotropium
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Perphenazine with Tiotropium?
MediHelp rates the interaction as minor. Perphenazine and Tiotropium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Perphenazine has weak to moderate anticholinergic activity that may add to the antimuscarinic effects of tiotropium. Dry mouth, constipation and urinary retention may be more frequent.
How serious is the interaction between Perphenazine and Tiotropium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic symptoms, especially in older patients or those with glaucoma or urinary retention.
What other medicines interact with Tiotropium?
MediHelp also lists interactions of Tiotropium with, for example, Glycopyrrolate inhaled, Indacaterol-glycopyrronium, Revefenacin. The full list is on the Tiotropium page.
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