Drug interactions
Perphenazine + Tranylcypromine
Severity: Moderate
Perphenazine and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining the two may add dopamine-blocking and serotonergic effects, with a risk of neuroleptic malignant syndrome or serotonin toxicity. Perphenazine can also add sedation, anticholinergic effects and hypotension.
What this interaction means in plain words
Perphenazine and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Perphenazine belongs to Central Nervous System; Tranylcypromine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effects from MAO inhibition and perphenazine's dopamine receptor blockade.
What to do
Use the lowest effective perphenazine dose and monitor for hyperthermia, rigidity, autonomic instability and orthostatic hypotension. Review the need for both agents regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Perphenazine with Tranylcypromine?
MediHelp rates the interaction as moderate. Perphenazine and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining the two may add dopamine-blocking and serotonergic effects, with a risk of neuroleptic malignant syndrome or serotonin toxicity. Perphenazine can also add sedation, anticholinergic effects and hypotension.
How serious is the interaction between Perphenazine and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective perphenazine dose and monitor for hyperthermia, rigidity, autonomic instability and orthostatic hypotension. Review the need for both agents regularly.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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