Drug interactions
Phendimetrazine + Prochlorperazine
Severity: Moderate
Phendimetrazine and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phendimetrazine is a sympathomimetic anorectic whereas prochlorperazine is a dopamine antagonist, so their effects partly oppose each other. Antipsychotics may reduce the anorectic effect, and the combination can add to tachycardia and arrhythmia risk in predisposed patients.
What this interaction means in plain words
Phendimetrazine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing dopaminergic and adrenergic pharmacodynamic effects; cardiac effects may be additive.
What to do
Monitor heart rate, blood pressure and ECG in patients with cardiac risk factors. Reassess the need for the stimulant if efficacy is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Phendimetrazine with Prochlorperazine?
MediHelp rates the interaction as moderate. Phendimetrazine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phendimetrazine is a sympathomimetic anorectic whereas prochlorperazine is a dopamine antagonist, so their effects partly oppose each other. Antipsychotics may reduce the anorectic effect, and the combination can add to tachycardia and arrhythmia risk in predisposed patients.
How serious is the interaction between Phendimetrazine and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG in patients with cardiac risk factors. Reassess the need for the stimulant if efficacy is lost.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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