Drug interactions
Phenelzine + Pregabalin
Severity: Moderate
Phenelzine and Pregabalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pregabalin causes sedation, dizziness and cognitive impairment, and phenelzine may add to CNS depression. The combination can increase drowsiness and impair coordination, particularly in older patients.
What this interaction means in plain words
Phenelzine and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Phenelzine belongs to Central Nervous System; Pregabalin belongs to Central Nervous System.
Why it happens
Additive central nervous system depression through pharmacodynamic synergism.
What to do
Use the lowest effective pregabalin dose, titrate slowly, and monitor for sedation, dizziness and respiratory depression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Other interactions of Pregabalin
Frequently asked questions
Can I take Phenelzine with Pregabalin?
MediHelp rates the interaction as moderate. Phenelzine and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pregabalin causes sedation, dizziness and cognitive impairment, and phenelzine may add to CNS depression. The combination can increase drowsiness and impair coordination, particularly in older patients.
How serious is the interaction between Phenelzine and Pregabalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective pregabalin dose, titrate slowly, and monitor for sedation, dizziness and respiratory depression.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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