Drug interactions
Phenelzine + Risperidone
Severity: Moderate
Phenelzine and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risperidone with phenelzine may cause additive hypotension and sedation. Serotonin toxicity or neuroleptic malignant syndrome are rare but possible when monoamine levels are raised together with dopamine blockade.
What this interaction means in plain words
Phenelzine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Phenelzine belongs to Central Nervous System; Risperidone belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effects of MAO inhibition with D2/5-HT2A antagonism and alpha-1 adrenergic blockade.
What to do
Monitor blood pressure, orthostatic symptoms, mental status and temperature when starting or changing doses. Stop the antipsychotic and treat urgently if features of serotonin toxicity or neuroleptic malignant syndrome appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Phenelzine with Risperidone?
MediHelp rates the interaction as moderate. Phenelzine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Risperidone with phenelzine may cause additive hypotension and sedation. Serotonin toxicity or neuroleptic malignant syndrome are rare but possible when monoamine levels are raised together with dopamine blockade.
How serious is the interaction between Phenelzine and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, orthostatic symptoms, mental status and temperature when starting or changing doses. Stop the antipsychotic and treat urgently if features of serotonin toxicity or neuroleptic malignant syndrome appear.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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