Drug interactions
Phenelzine + Rizatriptan
Severity: Contraindicated
Phenelzine and Rizatriptan: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenelzine inhibits MAO-A, the main route of rizatriptan clearance, causing high rizatriptan exposure. Serotonin syndrome and vasoconstriction risk rise. Labeling contraindicates use during and for 2 weeks after an MAOI.
What this interaction means in plain words
Phenelzine and Rizatriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Phenelzine belongs to Central Nervous System; Rizatriptan belongs to Central Nervous System.
Why it happens
MAO-A inhibition reduces rizatriptan metabolism and adds serotonergic effects.
What to do
Do not combine and wait 2 weeks after phenelzine before rizatriptan. Use an alternative migraine treatment.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Other interactions of Rizatriptan
- Almotriptan + Rizatriptan Contraindicated
- Dihydroergotamine intranasal + Rizatriptan Contraindicated
- Dihydroergotamine + Rizatriptan Contraindicated
- Eletriptan + Rizatriptan Contraindicated
- Ergoloid mesylates + Rizatriptan Contraindicated
- Ergotamine + Rizatriptan Contraindicated
Frequently asked questions
Can I take Phenelzine with Rizatriptan?
MediHelp rates the interaction as contraindicated. Phenelzine and Rizatriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phenelzine inhibits MAO-A, the main route of rizatriptan clearance, causing high rizatriptan exposure. Serotonin syndrome and vasoconstriction risk rise. Labeling contraindicates use during and for 2 weeks after an MAOI.
How serious is the interaction between Phenelzine and Rizatriptan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine and wait 2 weeks after phenelzine before rizatriptan. Use an alternative migraine treatment.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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