Drug interactions
Phenelzine + Sevoflurane
Severity: Moderate
Phenelzine and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Volatile anesthetics may produce exaggerated hypotension or labile hemodynamics in patients on MAO inhibitors. Perioperative management is more complex and interactions with other anesthetic drugs are possible.
What this interaction means in plain words
Phenelzine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Phenelzine belongs to Central Nervous System; Sevoflurane belongs to Central Nervous System.
Why it happens
Pharmacodynamic interaction between altered catecholamine handling due to MAO inhibition and anesthetic cardiovascular depression; not well characterized.
What to do
Alert the anesthesia team to phenelzine use and monitor blood pressure and heart rate closely during anesthesia. Use direct-acting vasopressors cautiously and avoid meperidine and indirect sympathomimetics.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Other interactions of Sevoflurane
Frequently asked questions
Can I take Phenelzine with Sevoflurane?
MediHelp rates the interaction as moderate. Phenelzine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Volatile anesthetics may produce exaggerated hypotension or labile hemodynamics in patients on MAO inhibitors. Perioperative management is more complex and interactions with other anesthetic drugs are possible.
How serious is the interaction between Phenelzine and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Alert the anesthesia team to phenelzine use and monitor blood pressure and heart rate closely during anesthesia. Use direct-acting vasopressors cautiously and avoid meperidine and indirect sympathomimetics.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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