Drug interactions
Phenelzine + Tiotropium-olodaterol
Severity: Major
Phenelzine and Tiotropium-olodaterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors can potentiate the cardiovascular effects of beta2 agonists, leading to palpitations, tachycardia, hypertension, and potentially arrhythmias. Olodaterol labeling advises caution with MAOIs and other agents that prolong QTc.
What this interaction means in plain words
Phenelzine and Tiotropium-olodaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Phenelzine belongs to Central Nervous System; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Reduced catecholamine metabolism by MAO inhibition potentiates adrenergic cardiovascular effects of olodaterol, with possible additive QT effects.
What to do
Use only if needed, with close monitoring of heart rate, blood pressure and ECG. Consider an alternative bronchodilator if cardiovascular symptoms occur.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tiotropium-olodaterol
Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Frequently asked questions
Can I take Phenelzine with Tiotropium-olodaterol?
MediHelp rates the interaction as major. Phenelzine and Tiotropium-olodaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. MAO inhibitors can potentiate the cardiovascular effects of beta2 agonists, leading to palpitations, tachycardia, hypertension, and potentially arrhythmias. Olodaterol labeling advises caution with MAOIs and other agents that prolong QTc.
How serious is the interaction between Phenelzine and Tiotropium-olodaterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only if needed, with close monitoring of heart rate, blood pressure and ECG. Consider an alternative bronchodilator if cardiovascular symptoms occur.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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